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Session: Poster Session 1 (Even numbers)
Session starts: Thursday 26 January, 16:00
Presentation starts: 16:00

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Pardis Farjam (University of Twente)
Edsko Hekman (University of Twente)
Gijsbetus Verkerke (University of Twente)
Jeroen Rouwkema (University of Twente)

Abstract:
Polyurethanes (PU) have been used in orthopaedic implants due to their superior characteristics including; good biocompatibility and mechanical properties, lubricity, and good wear properties. PU can be involved in a diverse range of orthopaedic applications including but not limited to joint replacement implants. We are currently designing a novel PU-based joint replacement prosthesis, for which we are investigating adhesives as a fixation mechanism to the bone. In orthopaedics, bone adhesives are commonly designed to treat simple and comminuted fractures. Bone adhesives could also be employed as the fixation technique of implants to bone. Adhesives as the anchorage tool bring several advantages, such as: preserving the integrity of the tissue and the implant with the possibility to be delivered via minimal-invasive techniques and offering simple and precise applicability. To be employed as an implant fixation technique, sufficient strength of an adhesive is one of the dominant requirements. Cyanoacrylate-based adhesives have shear bond strengths in the range of 1-2 MPa in a bone-bone bond. Purpose In this study, we evaluated a commercial biocompatible cyanoacrylate-based adhesive Glubran2® (Gem, Italy) as a candidate fixation technique for PU-based orthopaedic implants. Materials and Method PU film was obtained from our project partners at the Fraunhofer Institute for Manufacturing Engineering and Automation (Stuttgart, Germany). Square specimens of 25 mm*25 mm with a bonding area of 25 mm*10 mm were used. A lap-shear test has been conducted according to ASTM standards F2255 for strength properties of tissue adhesives in lap-shear by tension loading. Results The apparent shear strength as the maximum load divided by the bond area was revealed to be 0.07± 0.01 (MPa). Failure did predominantly occur at the bonding site between the cyanoacrylate-based adhesive and the PU film. Conclusion The biocompatible cyanoacrylate-based adhesive showed inferior shear strength in bonding PU to bone compared to bonding bone to bone. New fixation candidates will be studied for the fixation of PU-based joint replacement prostheses. Acknowledgements This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 863183.