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Session: Poster Session 1 (Even numbers)
Session starts: Thursday 26 January, 16:00
Presentation starts: 16:00

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Pascalle Wijntjes (University of Technology Eindhoven)
M.B. van der Hout-van der Jagt ()
W. Huberts ()
F.N. van de Vosse ()

Abstract:
Approximately 10% of all pregnancies are affected by hypertensive disorders, with 3% being affected by the more severe condition of pre-eclampsia. Studies show that multiple pregnancy complications are caused by abnormal placentation leading to placental dysfunction and severe complications. Therefore, it is important to look at the placenta vasculature in more detail. In this study, we will investigate if it is possible to gain more insights into the placenta physiology, i.e., its functioning and remodeling by creating a hemodynamic vasculature model of the placenta. This new knowledge could be used in (hybrid) prediction models for pregnancy complications like pre-eclampsia. A feto-placental vasculature model is created. For this, a space-filling algorithm is used to create the vessel tree within the given geometry, which defines the placenta and its functional segments (cotyledons). The model is assembled by assumptions made in the mathematical model based on literature and clinical knowledge. The resulting modelled placenta realistically mimics the placental vasculature on visual inspection. Further validation requires data that is not yet available to evaluate the vasculature details. However, the current model can be used to evaluate the hemodynamic functioning of the placenta for clinical scenarios. Simulations will be based on questions given by obstetricians. Ultimately, the goal is that this model and its simulations will in the future be able to support clinical decision-making and give a basis for new prediction models for pregnancy complications.