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Session: Poster session 2 (Odd numbers)
Session starts: Friday 27 January, 10:00
Presentation starts: 10:00

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Liselot Goris (Multi-Modality Medical Imaging group, University of Twente)
Srirang Manohar ()
Ioannis Sechopoulos ()

Abstract:
Purpose Dynamic contrast-enhanced dedicated breast CT (DCE-bCT) is a novel breast imaging technique in which functional information of the breast is captured by evaluating the contrast agent uptake and washout over time.1 This information could be useful for treatment planning, response monitoring, and prediction in patients with breast cancer.1 This research aims to validate and evaluate the quantitative accuracy of DCE-bCT imaging by performing a physical phantom study. Methods First, a method for real-time iodine contrast concentration monitoring in a breast phantom using optical absorption spectroscopy will be developed. The setup will include a pump for water and contrast bolus input, tubing, a light source that emits light through the cross-section of the tubing and a detector to capture the light spectrum. Additionally, a phantom with the ability to simulate the perfusion of fibroglandular and tumour tissue will be developed. With DCE-bCT, time-intensity curves of volumes of interest in the phantom will be obtained. The absorption spectroscopy setup will be extended to be used with the breast perfusion phantom in DCE-bCT. Fibre optic cables will be incorporated to quantify contrast flow in the phantom’s tissue compartments during DCE-bCT measurements without having the light source and detector inside the field of view. In the next step, the model will be expanded to simulate the perfusion of tumours with varying morphologies. The final step will be to use the phantom to evaluate the quantitative performance of different imaging modalities. Expected results The absorption spectra for different iodine contrast concentrations and the relation of the peak absorption to the iodine concentration will be evaluated. This relationship will be used to capture the contrast concentration over time with spectroscopy. This technique will be used to validate the contrast concentration over time estimated with DCE-bCT by comparing the results. Conclusion In this work, the plans for a phantom study to validate and evaluate quantitative DCE-bCT imaging are presented. The phantom may provide insights into other multi-modality breast perfusion imaging approaches too, such as DCE-MRI and DCE-DBT.